The p73 exhibits sequence homology to the p53's transcriptional activation, DNA binding, and oligomerization domains. However, adenovirus E1B 55K, simian virus 40 T, and human papillomavirus E6 do not physically interact with p73 indicating that the functions of these two proteins may differ under physiological conditions. This antibody does not cross-react with p53 or p53-related p51/Ket protein. p73 is expressed in either a full-length form ( ) (MW ~80kDa) or a shorter ( ) (MW ~70kDa) mRNA variant, with exon 13 spliced out. This antibody binds to both p73 and p73 in immunoprecipitation and Western Blot assays. Transient overexpression of p73 in cells can induce apoptosis and p21, a cellular p53 target gene primarily responsible for p53-dependent cell cycle arrest.
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