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PINK1 (G309D Mutant)

Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

Product Code: ax1084502 (100 µg) Categories: .

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Product Specification

Application Western blot|Immunohistochemistry|EIA
Host Rabbit
Size 100 µg
Species reactivity Human
Isotype IgG
Shipping conditions Ambient temperature
Storage conditions -20°C