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Pioglitazone HCl

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PPARg agonist CAS#: 112529-15-4 Citations: 1) Merck 14:7452 / 2) Sakamoto et al. (2000), Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone; Biochem.Biophys.Res.Commun., 278 704 / 3) Wilson et al. (2000), The PPARs: From Orphan Receptors to Drug Discovery; J.Med.Chem., 43 527

Product Code: ax133629 (10 mg)

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Product Specification

Function / pharmacology Pioglitazone is a clinically useful antidiabetic drug.1 It is a selective agonist of the human peroxisome proliferator-activated receptor γ1(PPARγ1; EC50 = 490 nM2, 550nM3) with weak agonist activity at PPARα and no activity at PPARδ.2
Chemical name 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Molecular weight 392.09
Molecular formula C19H20N2O3S ∙ HCl
Physical description White solid
Solubility DMSO (25 mg/ml)
Size 10 mg
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.