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Proprotein convertase subtilisin/kexin type 9 (PCSK9), LDLR-binding epitope blocking

This anitbody is made to an epitope that is reported to block the PCSK9-LDLR (low density lipoprotein receptor) interaction. PCSK9 binds to the EGF-A domain of the LDLR and signals LDLR degradation. Reduced LDLR levels result in decreased LDL (low density lipid) metabolism leading to hypercholesterolemia. _x000B__x000B_Additioanlly, PCSK9 may be implicated in the differentiation of cortical neurons and may also play a role in cholesterol homeostasis. Defects in PCSK9 gene are the cause of familial hypercholesterolemia 3 (FH3). The protein is thought to play a central role in cholesterol homeostais

Product Code: ax1084557 (100 µg) Categories: .

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Product Specification

Application Western Blot|Functional epitope reported to block PCSK9-LDLR interaction. ELISA
Host Rabbit
Size 100 µg
Species reactivity Human
Isotype IgG
Shipping conditions Ambient temperature
Storage conditions -20°C