Psoriasin (S-100 homolog)

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Axol's anti-human Psoriasin antibody detects psoriasin by both western blot and on formalin and paraffin fixed tissue sections. The staining on tissue sections is both nuclear and cytoplasmic. Although its expression in breast cancer is downregulated (in both preinvasive and invasive cancers) when its expression is maintained in breast cancer the expression of psoriasin is correlated with estrogen receptor negativity and node positivity and therefore with poor prognostic features. Further it is correlated with the degree of inflammation inthe tumor which is consistent with its being a chemotactic factor.