Loss of chromosome 10q is a frequently observed genetic defect in prostate cancer. Recently, the PTEN/MMAC1 tumor suppressor gene was identified and mapped to chromosome 10q23.3. PTEN is often found mutated in various cancers. The high frequency (60%) of PTEN mutations and deletions found in prostate cancer samples indicates a significant role of this tumor suppressor gene in the pathogenesis of prostate cancer. PTEN mRNA expression was clearly observed in all cell lines and xenografts without large homozygous deletions, showing that PTEN downregulation is not an important mechanism of PTEN inactivation. The immunogen used was a GST-pTEN fusion protein a.a. seq. 188-403.
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