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Purified anti-CD172b (SIRPβ1)

CD172b, also known as signal-regulatory protein beta and SIRP-beta, is a member of the signal regulatory protein family and immunoglobulin superfamily. CD172b contains a single pass transmembrane region with immunoglobulin-like domains and unlike CD172a, this receptor lacks a cytoplasmic SHP-2 binding domain. CD172b is a disulfide-linked homodimer with a predicted molecular weight of approximately 43 kD. Two isoforms of CD172b are produced by alternative splicing. CD172b is expressed on myeloid cells including monocytes and dendritic cells where it functions in the negative regulation of tyrosine-kinase coupled signaling processes. CD172b has been shown to regulate neutrophil transepithelial migration. CD172b interacts with DAP12 and Syk kinase (through TYROBP).

Product Code: ax33006612 (100 µl) Categories: .

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Features & Benefits

Higly Spesific Primary Antibodies

Product Specification

Application FC
Host Mouse
Specificity CD172b
Size 100 μl
Species reactivity Human
Clonality Monoclonal
Clone number B1D5
Isotype Mouse IgG2a
Shipping conditions Ambient temperature
Storage conditions +4°C
Formulation Phosphate-buffered solution.