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Purified anti-PAK2

PAK2 (p21-activated kinase 2) is a serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. It acts as the downstream effector of the small GTPases CDC42 and RAC1. PAK2 stimulates cell survival and cell growth, and knockdown of PAK2 induces cell cycle arrest. PAK2 is also implicated in the immune system. Loss of PAK2 results in reduced expression of multiple Treg functional molecules, including Foxp3, CD25, Nrp-1 and CTLA-4, coupled with a loss of Treg suppressive function in vitro and in vivo. The p21-activated kinases (PAKs) are the main effectors for the small Rho GTPases, critically involved in neurodevelopment, plasticity and maturation of the nervous system.

Product Code: ax33007371 (25 µg) Categories: .

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Features & Benefits

Higly Spesific Primary Antibodies

Product Specification

Application WB
Host Mouse
Specificity PAK2
Size 25 µg
Species reactivity Human
Clonality Monoclonal
Clone number P83B5/PAK2
Isotype Mouse IgG1
Shipping conditions Ambient temperature
Storage conditions +4°C
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.