PAK2 (p21-activated kinase 2) is a serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. It acts as the downstream effector of the small GTPases CDC42 and RAC1. PAK2 stimulates cell survival and cell growth, and knockdown of PAK2 induces cell cycle arrest. PAK2 is also implicated in the immune system. Loss of PAK2 results in reduced expression of multiple Treg functional molecules, including Foxp3, CD25, Nrp-1 and CTLA-4, coupled with a loss of Treg suppressive function in vitro and in vivo. The p21-activated kinases (PAKs) are the main effectors for the small Rho GTPases, critically involved in neurodevelopment, plasticity and maturation of the nervous system.
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