Protein phosphatase 2A (PP2A) is a heterotrimeric enzyme and is the most abundant phosphatase specific for serine- and threonine phosphorylation in mammalian cells. PP2A consists of a dimeric core enzyme composed of the structural A and catalytic C subunits, and a regulatory B subunit. When the PP2A catalytic C subunit associates with the A and B subunits several species of holoenzymes are produced with distinct functions and characteristics. The A subunit, a founding member of the HEAT repeat protein family (huntington-elongation-A subunit-TOR), is the scaffold required for the formation of the heterotrimeric complex. When the A subunit binds it alters the enzymatic activity of the catalytic subunit, even if the B subunit is absent. Multicellular eukaryotes express four classes of variable regulatory subunits: B (PR55), B′ (B56 or PR61), B″ (PR72), and B‴ (PR93/PR110), with at least 16 members in these subfamilies. In addition, accessory proteins and posttranslational modifications (such as methylation) control PP2A subunit associations and activities. Dephosphorylation of substrates targeted by PP2A plays a vital role in a large variety of cellular processes including signal transduction, regulation of the cell cycle, gene expression and development.
To place an order or request a quotation simply add the desired products to your shopping cart and then click "Process Checkout" to provide the billing and shipping information. On the payment page you can then either pay immediately or download a quotation.
Order Confirmed
Thank you for your order. We have received your purchase order successfully and will start processing it as soon as possible.
We will be in touch shortly.
Issue with Order Detected
There was an issue with your submitted order as follows: Unidentified Error Please resolve this issue and try again. If you are unable to do so, please contact us via the contact form and we'll do our best to resolve your issue.