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Purified anti-Tau Phospho (Ser396)

Paired helical filaments (PHFs) are the major building blocks of neurofibrillary lesions in Alzheimer's disease brains and are composed of hyperphosphorylated tau protein. Predominantly expressed in axons, alternatively spliced forms of tau comprise a family of microtubule-associated proteins that normally promote and stabilize the assembly of microtubules. PHF-tau differs from normal tau by its abnormal hyperphosphorylation, which results in decreased binding of tau to microtubules. The decreased affinity of PHF-tau for microtubules, coupled with reduced levels of normal tau, destabilizes microtubules leading to an impairment of axonal transport, neuronal death and the aggregation of PHFs. Therefore, hyperphosphorylation of tau is believed to be a key event in the pathogenesis of Alzheimer's disease.

Product Code: ax33006403 (25 µl) Categories: .

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Features & Benefits

Higly Spesific Primary Antibodies

Product Specification

Application IHC-P, WB
Host Mouse
Specificity Tau Phospho (Ser396)
Size 25 μl
Species reactivity Human
Clonality Monoclonal
Clone number PHF-13
Isotype Mouse IgG2b
Shipping conditions Ambient temperature
Storage conditions +4°C
Formulation Phosphate-buffered solution; no preservatives or carrier proteins.