Interferon-induced transmembrane protein domain containing 6 (IFITMD6), also known as TMEM91, dispanin C3 (DSPC3), and synapse differentiation-induced protein 3 (SynDIG3), is a member of the IFITM family of proteins which can inhibit invasion of pathogenic viruses, including HIV. Tmem91 is up-regulated in tumor-associated macrophages and mediate interferon response to viral infection.
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