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Puromycin Aminonucleoside

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Nephropathy inducer CAS#: 58-60-6 Citations: 1) Chow et al. (1995), Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis; Exp. Cell Res., 216 149 2) Krishnamurti et al. (2001), Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells; J. Am. Soc. Nephrol., 12 758 3) Egashira et al. (2006), Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis; Int. J. Vitam. Nutr. Res., 76 28 4) Hagiwara et al. (2006), Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis; Kidney Int., 69 1146 5) Lowenborg et al. (2000), Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats; Nephrol. Dial. Transplant, 15 1547

Product Code: ax44991 (10 mg)

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Product Specification

Function / pharmacology The nucleoside moiety of puromycin which does not inhibit protein synthesis or induce apoptosis1. It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.
Chemical name 3’-Amino-3’-deoxy-N6,N6-dimethyladenosine
Molecular weight 294.32
Molecular formula C12H18N6O3
Physical description White solid
Solubility Water (50 mg/ml)
Size 10 mg
Stability Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.