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Ribonucleoside-diphosphate reductase, large subunit (RRM1)

This protein is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in the S phase of dividing cells. The gene for RRM1 is, along with several others, located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region are associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. RRM1 plays an important role in malignancies and disease that involve this region.

Product Code: ax1084931 (100 µg) Categories: .

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Product Specification

Application Immunohistochemistry|Western Blot|ELISA
Host Rabbit
Size 100 µg
Species reactivity Human
Isotype Ig
Shipping conditions Ambient temperature
Storage conditions -20°C