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Ruxolitinib

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JAK inhibitor CAS#: 941678-49-5 Citations: 1) Verstovsek et al. (2009), Therapeutic potential of JAK2 inhibitors; Hematology Am. Soc. Hematol. Educ. Program, 2009(1) 636 2) Quintas-Cardama et al. (2010), Preclinical characterization of the selective JAK1/2 inhibitor INCB01824: Therapeutic implications for the treatment of myeloproliferative neoplasms; Blood, 115 3109

Product Code: ax132936 (5 mg)

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Product Specification

Function / pharmacology ATP-competitive inhibitor of Janus-associated kinase 1 and 2. (IC50’s of 2.7, 4.5 and 322 nm for JAK1, JAK2 and JAK3 respectively).1,2 Clinically useful cancer chemotherapeutic.
Chemical name βR-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile
Molecular weight 306.37
Molecular formula C17H18N6
Physical description White solid
Solubility DMSO (5 mg/ml) Ethanol (10 m/ml)
Size 5 mg
Stability Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.