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SH21A (SH2 DOMAIN-CONTAINING PROTEIN 1A) / (SAP)

SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.

Product Code: ax1085008 (100 µg) Categories: .

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Product Specification

Application Western Blot|Immunoprecipitation
Host Rabbit
Size 100 µg
Species reactivity Human
Isotype IgG
Shipping conditions Ambient temperature
Storage conditions -20°C