Recognizes human SH2 (Src homology 2) domain-Leukocyte Protein of 76 kDa. _x000B__x000B_SLP-76 is a substrate of the TCR- stimulated protein tyrosine kinase that function in hte signal transduction cascade linking the TCR with IL-2 gene expression. Alignment of murine and human SLP-76 nucleic acid (80% identity) and predicted protein sequences (84% idnetity) indicates a very high degree of sequence homology. Human and murine SLP-76 mRNA demonstrate an identical pattern of tissue-specific expression. In human SLP-76 mRNA is abundantly expressed in human spleen, thymus and peripheral blood leucocytes, T-cells and monocytic cell lines, but a low level of expression in B cells.
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