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Sunitinib malate

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VEGFR, PDGFR kinase inhibitor CAS#: 341031-54-7 Citations: 1) Deeks et al. (2006), Sunitinib; Drugs, 66 2255 2) Guo et al. (2006), Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors Mol. Cancer. Ther., 5 1007 3) O’Farrell et al. (2003), SU11248 is a novel FLT3 yrosine kinase with potent activity in vitro and in vivo; Blood 101 3597 4) Roskoski et al. (2007), Sunitinib: a EGF and PDGF receptor protein kinase and angiogenesis inhibitor; Biochem. Biophys. Res. Commun., 356 323

Product Code: ax134289 (5 mg)

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Product Specification

Function / pharmacology A potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRβ and Kit (Ki = 2-17 nM)1. Also inhibits cFMS (IC50=7 nM)2 and FLT33. Potent inhibitor of angiogenesis4. Clinically useful anticancer agent. Cell permeable.
Chemical name N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimehyl-1H-pyrrole-3-carboxamide malate
Molecular weight 532.57
Molecular formula C22H27FN4O4 ∙ C4H6O5
Physical description Orange solid
Solubility DMSO (13 mg/ml)
Size 5 mg
Stability Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.