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This antibody recognizes the 19 kDa protein, -synuclein, which belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. The epitope maps to amino acid residues 121-125 of human -synuclein. -synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble A into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of ParkinsonÕs disease, and is also observed in senile plaques of AlzheimerÕs disease patients. Human -synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.

Product Code: ax1085470 (100 µg) Categories: .

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Product Specification

Application ELISA|Western Blot|Immunohistochemistry
Host Mouse
Size 100 µg
Species reactivity Human.
Clone number Syn 211
Isotype IgG1
Shipping conditions Ambient temperature
Storage conditions -20°C