This antibody recognizes the 19 kDa protein, -synuclein, which belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. The epitope maps to amino acid residues 121-125 of human -synuclein. -synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble A into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of ParkinsonÕs disease, and is also observed in senile plaques of AlzheimerÕs disease patients. Human -synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.
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