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Toll interacting protein (TOLLIP/TOLIP) ( (IN))

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules to activate various kinases and transcription factors (3) so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation (4). This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.

Product Code: ax1085602 (100 µg) Categories: .

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Product Specification

Application Western Blot|Immunohistochemistry (Paraffin)
Host Rabbit
Size 100 µg
Species reactivity Human|Mouse|Rat
Isotype IgG
Shipping conditions Ambient temperature
Storage conditions -20°C