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Triacsin C

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Acyl-CoA synthase inhibitor CAS#: 76896-80-5 Citations: 1) Hartman et al. (1989), Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase; Prostaglandins, 37 655 2) Namatame et al. (1999), Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C; J. Biochem, 125 319 3) Matsuda et al. (2008), Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibiitor; J. Antibiot. (Tokyo), 61 318

Product Code: ax45046 (100 µg)

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Product Specification

Function / pharmacology Long-chain fatty acyl CoA synthetase inhibitor (IC50=3.6-8.7 μM)1. Inhibits mouse macrophage-derived foam cell formation2 and displays anti-atherosclerotic activity3. Cell permeable.
Chemical name (3E)-1-Hydroxy-3-((2E,4Z,7E)-undeca-2,4,7-triene-1-ylidene)triaz-1-ene
Molecular weight 207.28
Molecular formula C11H17N3O
Physical description Solution in DMSO
Solubility Supplied in solution in DMSO at 1 mg/ml. Maximum solubility in DMSO is 25 mg/ml
Size 100 µg
Stability Stable for 1 year as supplied. Solutions further diluted with DMSO may be stored at -20°C for up to 2 months.