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URB-597

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FAAH inhibitor CAS#: 546141-08-6 Citations: 1) Piomelli et al. (2006), Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597); CNS Drugs Rev., 12 21 2) Jayamanne et al. (2006), Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models; Br. J. Pharmacol., 147 281 3) Zaitone et al. (2012), Inhibition of fatty acid amide hydrolase by URB597 attenuates the anxiolytic-like effect of acetaminophen in the mouse elevated plus-maze test; Behav. Pharmacol., 23 417 4) Murphy et al. (2012), The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation; Neuroinflamation, 9 79 5) Bosier et al. (2013), The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB- and FAAH-independent mechanisms; Br. J. Pharmacol., 169 794

Product Code: ax42681 (5 mg)

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Product Specification

Function / pharmacology Potent and selective fatty acid amide hydrolase (FAAH) inhibitor, IC50 = 3-5 nM1. Produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states without causing side effects associated with cannabinoid receptor activation2. Attenuates the anxiolytic-like effect of acetaminophen in a mouse model3. Exerts anti-inflammatory effects in rat hippocampus and ameliorates age-related deficits4. Off target effects: Reduces tyrosine hydroxylase expression5.
Chemical name Cyclohexylcarbamic acid 3’-(aminocarbonyl)-[1,1’-biphenyl]-3-yl ester
Molecular weight 338.41
Molecular formula C20H22N2O3
Physical description Off-white solid
Solubility DMSO (15 mg/ml)
Size 5 mg
Stability Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.