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YM-254890

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Gq inhibitor (G-protein) CAS#: 568580-02-9 Citations: 1) Takasaki (2004), A novel Galphaq/11-selective inhibitor; J. Biol. Chem., 279 47438 2) Uemura et al. (2006), Biological properties of a specific Galpha q/11 inhibitor, YM-254890, on platelet functions and thrombus formation under high-shear stress; Br. J. Pharmacol., 148 61 3) Orth et al. (2005), Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}g and G{alpha}12/13; J. Biol. Chem., 280 36701 4) Mizuno and Itoh (2009), Functions and regulatory mechanisms of Gq-signaling pathways; Neurosignals, 17 42

Product Code: ax44496 (100 µg)

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Product Specification

Function / pharmacology YM-254890 is a novel Gαq/11 inhibitor,1 U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not2 (IC50 = 0.1-0.2 μM)1. It blocks Pasteurella multocida toxin-mediated activation of Gαq.3 A highly useful new tool for studying Gαq/11-coupled receptor signaling and resulting cellular events.4
Chemical name Cyclic depsipeptide from Chromobacterium sp.
Molecular weight 960.1
Molecular formula C46H69N7O15
Physical description White or off-white lyophilize solid
Solubility DMSO (10 mg/ml)
Size 100 ug
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.