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Aurora B kinase inhibitor CAS#: 331771-20-1 Citations: 1) Ditchfield et al (2003) Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J.Cell Biol. 161 267 / 2) Girdler et al (2006) Validating Aurora B as an anti-cancer drug target. J.Cell Sci. 119 3664

Product Code: ax133915 (1 mg)

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Product Specification

Function / pharmacology ZM-447439 is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 µM, Aur C IC50 = 250 nM at physiological ATP concentrations2, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). It did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis.1,2
Chemical name N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Molecular weight 513.59
Molecular formula C29H31N5O4
Physical description White solid
Solubility DMSO (50 mg/ml) Ethanol (25 mg/ml)
Size 1 mg
Stability Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.